Journal of magnetic resonance imaging : JMRI
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J Magn Reson Imaging · Oct 2015
Glycosaminoglycan chemical exchange saturation transfer of lumbar intervertebral discs in patients with spondyloarthritis.
To assess glycosaminoglycan (GAG) content of lumbar intervertebral discs (IVD) in patients with spondyloarthritis (SpA) using glycosaminoglycan chemical exchange saturation transfer (gagCEST). ⋯ GagCEST analysis of morphologically nondegenerative IVDs (Pfirrmann score 1 and 2) in T2 w images demonstrated significantly lower GAG values in patients with spondyloarthritis in NP and AF, possibly representing a depletion of GAG in spondyloarthritis in the absence of morphologic degeneration.
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J Magn Reson Imaging · Oct 2015
Differentiating benign from malignant vertebral fractures using T1 -weighted dynamic contrast-enhanced MRI.
To differentiate pathologic from benign vertebral fractures, which can be challenging. We hypothesized that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can aid in the noninvasive distinction between pathologic and benign fractures. ⋯ Our data demonstrate that T1 -weighted DCE-MRI has potential to differentiate between pathologic vs. benign, acute vs. chronic, and most important, benign acute vs. pathologic vertebral fractures.
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J Magn Reson Imaging · Oct 2015
Controlled Clinical TrialTest-retest reliability of cerebral blood flow and blood oxygenation level-dependent responses to hypercapnia and hyperoxia using dual-echo pseudo-continuous arterial spin labeling and step changes in the fractional composition of inspired gases.
To assess the reproducibility of blood oxygenation level-dependent / cerebral blood flow (BOLD/CBF) responses to hypercapnia/hyperoxia using dual-echo pseudo-continuous arterial spin labeling (pCASL) and step changes in inspired doses. ⋯ It is possible to attain reproducible measures of the simultaneous BOLD and CBF responses to blood gases, within a reasonable scan time and with whole brain coverage, using a simple respiratory manipulation and dual-echo pCASL.
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J Magn Reson Imaging · Oct 2015
Comparative StudyComparison of stretched-Exponential and monoexponential model diffusion-Weighted imaging in prostate cancer and normal tissues.
To compare stretched-exponential and monoexponential model diffusion-weighted imaging (DWI) in prostate cancer and normal tissues. ⋯ The stretched-exponential model DWI provides more parameters for distinguishing prostate cancer and normal tissue and reveals slight differences between DDC and ADC values.
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J Magn Reson Imaging · Oct 2015
Minimization of errors in biexponential T2 measurements of the prostate.
To determine the echo times that provide the greatest precision in measurements of prostate T2s. T2 relaxation time measurements in the prostate are complicated by the structure of prostate tissue, which consists of fluid-filled glands surrounded by epithelial and stromal cells. Since the glands are large relative to diffusion distances, there is little water exchange between the two compartments and T2s are biexponential. Because the relative size and characteristics of the two compartments change in prostate tumors, accurate measurement of the characteristics of each may provide useful information on tumor grade. ⋯ Use of optimum echo times can substantially improve the precision of biexponential T2 measurements. This optimization is anticipated to improve prostate cancer characterization using T2 measurements.