Journal of magnetic resonance imaging : JMRI
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The noninvasive assessment of lung function using imaging is increasingly of interest for the study of lung diseases, including chronic obstructive pulmonary disease (COPD) and asthma. Hyperpolarized gas MRI (HP MRI) has demonstrated the ability to detect changes in ventilation, perfusion, and lung microstructure that appear to be associated with both normal lung development and disease progression. ⋯ Clinical investigations using HP MRI to study asthma, COPD, cystic fibrosis, pediatric chronic lung disease, and lung transplant are reviewed. Recent advances in polarization, pulse sequence development for imaging with Xe-129, and prototype low magnetic field systems dedicated to lung imaging are highlighted as areas of future development for this rapidly evolving technology.
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J Magn Reson Imaging · May 2007
Comparative StudyMRCP imaging at 3.0 T vs. 1.5 T: preliminary experience in healthy volunteers.
To evaluate the impact of magnetic resonance cholangiopancreatography (MRCP) imaging at 1.5T and 3.0T on image quality. ⋯ Our experience suggests that MRCP imaging at 3.0T has the potential to provide excellent images. High-resolution heavily T2W imaging with a small voxel size (1.3 x 1.3 x 1.4 mm) at 3.0T can provide diagnostic images and allow evaluation of small pathologies of the bile and pancreatic ducts, which 1.5T MRI cannot sufficiently visualize.
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J Magn Reson Imaging · May 2007
Multiple regression method for pulmonary apparent diffusion coefficient measurement by hyperpolarized 3He MRI.
To develop and validate a new multiple regression technique for the separation of flip angle effect in pulmonary apparent diffusion coefficient (ADC) measurement. ⋯ With the introduction of a nonlinear progression in the diffusion-sensitization gradients, the multiple regression technique is capable of separating the flip angle effect in ADC measurement. In addition, this technique can perform a rigorous measurement uncertainty analysis and provide the optimal scan parameters that yield best noise performance.
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J Magn Reson Imaging · May 2007
FAIR-TrueFISP imaging of cerebral perfusion in areas of high magnetic susceptibility differences at 1.5 and 3 Tesla.
To estimate cerebral blood perfusion in areas of strong magnetic susceptibility changes with high spatial and temporal resolution using a flow-sensitive alternating inversion recovery (FAIR) arterial spin labeling (ASL) method. ⋯ FAIR-TrueFISP allows for assessment of cerebral perfusion in areas of critically high susceptibility changes with conventional ASL methods.
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J Magn Reson Imaging · Apr 2007
Superparamagnetic iron oxide (SPIO)-enhanced liver MRI with ferucarbotran: efficacy for characterization of focal liver lesions.
To evaluate the efficacy of ferucarbotran in T2-weighted (T2W) fast spin-echo (FSE) and T2*W gradient-echo (GRE) sequences for characterizing focal liver lesions. ⋯ The PSIL can be an accurate tool for characterizing benign and malignant lesions. The addition of a CE-T2*W GRE sequence is helpful for the detection and characterization of malignant lesions.