Journal of magnetic resonance imaging : JMRI
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J Magn Reson Imaging · May 2017
ReviewLiver fibrosis: Review of current imaging and MRI quantification techniques.
Liver fibrosis is characterized by the accumulation of extracellular matrix proteins such as collagen in the liver interstitial space. All causes of chronic liver disease may lead to fibrosis and cirrhosis. The severity of liver fibrosis influences the decision to treat or the need to monitor hepatic or extrahepatic complications. ⋯ Further, some techniques are only available on MRI-such as spin-lattice relaxation time in the rotating frame (T1 ρ), diffusion of water molecules, and hepatocellular function based on the uptake of a liver-specific contrast agent-remain investigational in the setting of liver fibrosis staging. In this review, we summarize the key concepts, advantages and limitations, and diagnostic performance of each technique. The use of multiparametric MRI techniques offers the potential for comprehensive assessment of chronic liver disease severity.
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J Magn Reson Imaging · May 2017
Brain white matter changes in CPAP-treated obstructive sleep apnea patients with residual sleepiness.
To investigate white matter (WM) structural alterations using diffusion tensor imaging (DTI) in obstructive sleep apnea (OSA) patients, with or without residual sleepiness, following adherent continuous positive airway pressure (CPAP) treatment. Possible quantitative relationships were explored between the DTI metrics and two clinical assessments of somnolence. ⋯ Global and regional WM alterations, as revealed by DTI, can be a possible mechanism to explain why OSA patients with high levels of CPAP use can have differing responses to treatment. Compromised myelin sheath, indicated by increased radial diffusivity, can be involved in the underlying WM changes. Evidence level: 1 J. MAGN. RESON. IMAGING 2017;45:1371-1378.
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J Magn Reson Imaging · May 2017
In vivo triglyceride composition of abdominal adipose tissue measured by 1 H MRS at 3T.
To investigate the regional variability of adipose tissue triglyceride composition in vivo using 1 H MRS, examining potential confounders and corrections for artifacts, to allow for adipose tissue spectrum estimation. ⋯ 2 J. MAGN. RESON. IMAGING 2017;45:1455-1463.
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J Magn Reson Imaging · May 2017
Separation of benign and malignant breast lesions using dynamic contrast enhanced MRI in a biopsy cohort.
To assess the diagnostic utility of contrast kinetic analysis for breast lesions and background parenchyma of women undergoing MRI-guided biopsies, for whom standard clinical analysis had failed to separate benign and malignant lesions. ⋯ 3 J. MAGN. RESON. IMAGING 2017;45:1385-1393.
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J Magn Reson Imaging · Apr 2017
Comparative StudyStaging liver fibrosis in chronic hepatitis B with T1 relaxation time index on gadoxetic acid-enhanced MRI: Comparison with aspartate aminotransferase-to-platelet ratio index and FIB-4.
To assess the accuracy of the T1 relaxation time index on gadoxetic acid-enhanced magnetic resonance imaging (MRI) for staging liver fibrosis in chronic hepatitis B (CHB), in comparison and combination with the aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 (FIB-4). ⋯ 4 J. Magn. Reson. Imaging 2017;45:1186-1194.