Fetal diagnosis and therapy
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Fetal. Diagn. Ther. · Jan 2008
Review Case ReportsPrenatal diagnosis and subsequent treatment of an intermediate-risk paraspinal neuroblastoma: case report and review of the literature.
Neuroblastoma is the most common extracranial solid tumor of childhood, and the most common malignancy diagnosed during infancy. In comparison, neonatal neuroblastoma is relatively rare. Improvements in prenatal imaging and widespread use of fetal ultrasonography have led to an increased rate of prenatal diagnoses. ⋯ Prenatal diagnosis of neuroblastoma, management and outcomes are reviewed. Prompt diagnosis can strongly influence perinatal management and improve prognosis.
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Fetal. Diagn. Ther. · Jan 2008
ReviewFetal spina bifida repair--current trends and prospects of intrauterine neurosurgery.
Myelomeningocele is a common dysraphic defect leading to severe impairment throughout the patient's lifetime. Although surgical closure of this anomaly is usually performed in the early postnatal period, an estimated 330 cases of intrauterine repair have been performed in a few specialized centers worldwide. It was hoped prenatal intervention would improve the prognosis of affected patients, and preliminary findings suggest a reduced incidence of shunt-dependent hydrocephalus, as well as an improvement in hindbrain herniation. ⋯ The primary study endpoints include the need for shunt at 1 year of age, and fetal and infant mortality. No data from the trial will be published before the final analysis has been completed in 2008, and until then, the number of centers offering intrauterine MMC repair in the USA is limited to 3 in order to prevent the uncontrolled proliferation of new centers offering this procedure. In future, refined, risk-reduced surgical techniques and new treatment options for preterm labor and preterm rupture of the membranes are likely to reduce associated maternal and fetal risks and improve outcome, but further research will be needed.
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Fetal. Diagn. Ther. · Jan 2008
Case ReportsMirror syndrome associated with hydropic acardius in triplet pregnancy.
Mirror syndrome is the association of triple edema, i.e. fetal, placental and maternal edema, with maternal preeclampsia. We here report the first case of mirror syndrome resulting from hydropic acardius in triplet pregnancy. ⋯ When dealing with multifetal pregnancy, especially when complicated by an acardius, obstetricians must have the highest level of concern for the occurrence of mirror syndrome, a life-threatening condition both to the mother and the fetus.
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Fetal. Diagn. Ther. · Jan 2007
Case ReportsSuccessful intrauterine therapy for congenital cystic adenomatoid malformation of the lung. A case report.
Congenital cystic adenomatoid malformation (CCAM) of the lung is a rare abnormality which is amenable to be diagnosed by prenatal ultrasonography. In general, CCAM associated with non-immune hydrops has a poor prognosis unless a fetal intervention is performed. In some series almost 100% of either prenatal or early neonatal deaths are observed without intervention. ⋯ At 37 weeks a male infant was born vaginally weighing 3,210 g with Apgar scores of 5 and 10. Resection of the mass was performed uneventfully on day 3. The infant is currently 22 months of age, asymptomatic and in good condition.
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Fetal. Diagn. Ther. · Jan 2007
Multicenter StudyNonimmune hydrops fetalis diagnosed during the second half of pregnancy in Southern China.
To analyze the etiologies of nonimmune hydrops fetalis (NIHF) for a southern section of China. ⋯ Homozygous alpha-thalassemia is the most common cause of NIHF in southern China. An effective prenatal thalassemia screening program should be established in this high prevalence region.