Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
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Anasthesiol Intensivmed Notfallmed Schmerzther · Mar 2002
[In-vitro-effects of cocaine in skeletal muscle specimens of patients susceptible to malignant hyperthermia].
The abuse of cocaine can cause serious medical complications like tachycardia, rhabdomyolysis, and hyperthermia. Because of the clinical similarities, it has been suggested that cocaine might be a trigger of malignant hyperthermia (MH). Therefore, aim of this study was to investigate the in-vitro effects of cocaine in skeletal muscle specimens of MH susceptible (MHS) and normal (MHN) patients. ⋯ In contrast to the established MH trigger substances like volatile anaesthetics, cocaine produced no contracture development in MHS muscle specimens. Furthermore, cocaine produced a negative inotropic effect in all skeletal muscle preparations, which might be explained by local anaesthetic effects. Regarding these results, cocaine seems not to be a MH trigger agent.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Feb 2002
Review[Anesthesia in neuromuscular disorders. Part 1: introduction].
Disorders of skeletal muscle and peripheral nervous system are collectively called neuromuscular disorders (NMD). Important for anesthesia is that these disorders show various symptoms and have a high risk during general anesthesia. Especially administration of succinylcholine and volatile anaesthetics may cause problems. ⋯ It is obligate to monitor neuromuscular function and body temperature. During recovery special attention should be paid to maintain normal body temperature and electrolytes and acid-base status. The discharge of the patient from the recovery area to the normal ward should be performed only after respiratory function is normalized.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Feb 2002
Comparative Study Clinical Trial Controlled Clinical Trial[Clonidine vs. Midazolam for premedication - comparison of the anxiolytic effect by using the STAI-test].
Many investigations described a positive effect of clonidine for premedication (reduction of perioperative stress response, analgetic effect, anaesthetic-saving effect, prophylaxis of postoperative shivering). The most important objective in premedication is undisputed anxiolysis. The anxiolytic effect of clonidine is differently discussed. Therefore we investigated the anxiolytic effect of clonidine in comparison to midazolam. ⋯ In addition to the higher up listed effects clonidine showed a anxiolytic effect, which is comparable to midazolam. Therefore clonidine is an interesting alternative to benzodiazepines, which are commonly used drugs for premedication.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Feb 2002
Review[Tumescent technique for local anesthesia].
Tumescent local anesthesia was originally used in liposuction but is also carried out for other plastic, cosmetic, dermatological procedures and for surgery of the venous system, often in outpatients. For this purpose, large amounts of fluids containing diluted lidocaine or prilocaine and epinephrine are infused subcutaneously. In this review of the literature, this technique is assessed in view of potential anesthesiological complications such as intoxication with lidocaine, prilocaine, overdosage of epinephrine or overload with fluids. ⋯ Because of these possible complications, tumescent local anesthesia should be employed in outpatients with great care. Patients should be monitored during the procedure and for a sufficient period of time thereafter by adequately trained staff. Patients with cardiac or pulmonary risk factors should not undergo tumescent local anesthesia.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Feb 2002
Case Reports[Caesarean section after severe trauma and cardiac arrest - a case report].
A 40 year-old woman with a prominent abdomen was hit by a car on the motorway. The emergency call was "cardiac arrest after multiple trauma in a woman in the late stages of pregnancy". The patient was asystole as indicated by the electrocardiogram 6 minutes after the primary emergency call. ⋯ The skills of the emergency physicians and the conditions at the site of the emergency have to be weighed carefully against the expected time that is needed to reach the next hospital where a caesarean section can be performed under controlled conditions. In this case, both emergency physicians were anaesthesiologists and they had no doubt that the patient was in the late stages of pregnancy. Due to the prolonged cardiac arrest that did not respond to cardiopulmonary resuscitation both physicians were convinced that immediate preclinical caesarean section represented the only therapeutical option for the unborn patient.