Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
-
Anasthesiol Intensivmed Notfallmed Schmerzther · Jun 1998
Clinical Trial[Ventilation-perfusion distribution with volume-reduced, pressure-limited ventilation with permissive hypercapnia].
Low volume pressure-limited ventilation with permissive hypercapnia (PH) may decrease the mechanical stress of the lung in acute respiratory insufficiency. Alveolar PCO2 is a determinant of regional ventilation, whereas increased mixed-venous and arterial PCO2 may affect systemic and pulmonary haemodynamics. The aim of this study was to analyse the ventilation-perfusion (VA/Q) distribution during controlled ventilation with permissive hypercapnia. ⋯ The mechanical ventilation with permissive hypercapnia may increase shunt due to alveolar derecruitement and an impaired hypoxic pulmonary vasoconstriction. PaO2 was unchanged due to an increased CO, PvO2 and--to a lesser extent--shift of the oxyhaemoglobin dissociation curve.
-
Anasthesiol Intensivmed Notfallmed Schmerzther · May 1998
Randomized Controlled Trial Comparative Study Clinical Trial[Desflurane versus isoflurane in geriatric patients. A comparison of psychomotor and postoperative well-being following abdominal surgical procedures].
The new volatile anaesthetic agent desflurane has a significantly lower blood-gas partition coefficient (0.42) than isoflurane (1.4), suggesting excellent intraoperative control of anaesthesia and rapid emergence and recovery from anaesthesia. However, only limited experience is available in geriatric patients undergoing major abdominal surgery. ⋯ Using a balanced anaesthesia technique, we found desflurane as suitable as isoflurane for geriatric patients. Additionally, due to the fast emergence from anaesthesia, an improved cooperativity was found. In the DES group overall better postoperative psychomotor performance resulted in a shortening of discharge times from the recovery room. Hence, desflurane anaesthesia may be advantageous in geriatric patients.