Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth. · Feb 2004
Randomized Controlled Trial Comparative Study Clinical TrialA prospective, randomized study of endothelin and postoperative recovery in off-pump versus conventional coronary artery bypass surgery.
The objectives are 2-fold: (1). to serially determine endothelin (ET) levels in arterial vascular compartments in patients undergoing coronary artery bypass surgery using either cardiopulmonary bypass or off-pump techniques, and (2). to define potential relationships between endothelial levels and specific perioperative parameters of patient recovery. ⋯ Postoperative ET levels were higher in patients who underwent CPB for coronary artery bypass surgery. Increased ET in the postoperative period may contribute to a more complex recovery from coronary artery bypass surgery in patients undergoing cardiopulmonary bypass.
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J. Cardiothorac. Vasc. Anesth. · Feb 2004
Randomized Controlled Trial Clinical TrialThe effect of intravenous quinaprilat on plasma cytokines and hemodynamic variables during cardiac surgery.
Perioperative treatment with angiotensin-converting enzyme (ACE) inhibitors in cardiac surgery with cardiopulmonary bypass is still controversial. Using ACE inhibitors during cardiac surgery might be associated with an increased risk of critical hypotensive episodes. On the other hand, ACE inhibitors could have beneficial effects with respect to the development of the systemic inflammatory response syndrome. ⋯ The present investigation shows that acute administration of an intravenous ACE inhibitor, quinaprilat, has no influence on proinflammatory cytokines during cardiac surgery with cardiopulmonary bypass. The patients treated with quinaprilat showed an improved systemic vascular resistance index with no increased risk of deleterious hemodynamic episodes.
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J. Cardiothorac. Vasc. Anesth. · Feb 2004
Randomized Controlled Trial Clinical TrialPostoperative intravenous iron used alone or in combination with low-dose erythropoietin is not effective for correction of anemia after cardiac surgery.
The aim of this study was to examine whether intravenous iron III-hydroxide sucrose complex (IHSC) used alone was sufficient to provide rapid correction of anemia after cardiac surgery and whether additional stimulation of erythropoiesis is possible by means of a single low dose of recombinant-human erythropoietin (r-HuEPO) administration. ⋯ Postoperative intravenous iron supplementation alone or in combination with a single dose of r-HuEPO (300 U/kg) is not effective in correcting anemia after cardiac surgery.
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J. Cardiothorac. Vasc. Anesth. · Feb 2004
Randomized Controlled Trial Clinical TrialSimilar pain scores after early and late extubation in heart surgery with cardiopulmonary bypass.
To investigate if early extubation, 2 hours after surgery, would result in more postoperative pain or in an increased use of opioid analgesics compared with late extubation, 6 hours after surgery. ⋯ Early extubation had no negative effect on the quality of postoperative pain control and was not followed by an increased use of analgesics.