Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth. · Apr 2005
The mechanisms of the direct vascular effects of fentanyl on isolated human saphenous veins in vitro.
The purpose of this study was to determine the mechanism of the direct effects of fentanyl on human veins in vitro. ⋯ The present results show that fentanyl causes vasodilatation via both endothelium- and opioid receptor-independent mechanisms in the human saphenous vein. The relaxant effects of fentanyl are probably via activation of K+ channel and Na+K+-adenosine trisphosphatase and inhibition of Ca++ channel.
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J. Cardiothorac. Vasc. Anesth. · Apr 2005
Normobaric hyperoxia reduces cardiac index in patients after coronary artery bypass surgery.
The purpose of this study was to assess the hemodynamic changes in response to normobaric hyperoxia in patients immediately after coronary artery bypass surgery. ⋯ Exposing patients after coronary artery surgery to hyperoxia induces significant hemodynamic changes.