Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth. · Aug 2019
Observational StudyEffective Dose of Landiolol, an Ultra-Short-Acting β-Blocker, to Decrease Heart Rate During On-Pump, Beating Coronary Artery Bypass Grafting.
Decreasing the heart rate (HR) using landiolol, an ultra-short-acting β-blocker, is helpful for completing a meticulous distal anastomosis during on-pump or off-pump, beating coronary artery bypass grafting (CABG) surgery. We determine the effectiveness of landiolol to decrease the HR because the most effective dose has not been established. ⋯ Landiolol maximally decreased HR just over 20% of the baseline HR. Hence, landiolol 25 μg/kg/min is likely a sufficient dose during LITA-LAD anastomosis during on-pump, beating CABG.