Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth.
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J. Cardiothorac. Vasc. Anesth. · Apr 2011
Meta Analysis Comparative StudyN-acetylcysteine in cardiac surgery: do the benefits outweigh the risks? A meta-analytic reappraisal.
N-acetylcysteine (NAC) reduces proinflammatory cytokines, oxygen free-radical production, and ameliorates ischemia reperfusion injury; therefore, it may theoretically reduce postoperative complications in cardiac surgery. The aim of this study was to determine, through systematic review and meta-analysis of all relevant randomized trials, whether NAC reduces mortality, morbidity, or resource utilization in cardiac surgery. ⋯ Current evidence shows that the perioperative use of NAC has no proven benefit or risk on clinically important outcomes in patients undergoing cardiac surgery.