Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth.
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J. Cardiothorac. Vasc. Anesth. · Apr 2011
Comparative StudyPropofol inhibits desflurane-induced preconditioning in rabbits.
The authors tested the hypothesis that ischemic and desflurane-induced preconditioning are blocked by propofol. ⋯ Desflurane-induced preconditioning markedly reduced infarct size and was blocked by propofol, whereas ischemic preconditioning was not blocked by propofol. The results suggest an important interference between propofol and anesthetic-induced preconditioning and might explain some contradictory findings in studies in humans.