Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth.
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J. Cardiothorac. Vasc. Anesth. · Dec 2024
Randomized Controlled Trial Multicenter Study Comparative StudyThe Effects of Angiotensin II versus Norepinephrine on Pulmonary Vascular Resistance in Cardiac Surgery: Post Hoc Analysis of a Randomized Controlled Trial.
To assess whether angiotensin II infusion increases pulmonary vascular resistance (PVR) relative to norepinephrine. ⋯ The results of this study suggest that in cardiac surgery patients and at doses used in the prior feasibility study, angiotensin II did not have significant effects on the pulmonary vasculature compared with norepinephrine. Moreover, at doses used in this study, neither drug appeared to have a substantial effect on the pulmonary circulation relative to surgical and patient factors.