Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth.
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J. Cardiothorac. Vasc. Anesth. · Aug 2010
Comparative StudyIncreased alveolar damage after mechanical ventilation in a porcine model of thoracic surgery.
Mechanical stress during one-lung ventilation (OLV) results in lung injury. This study compared the effects of mechanical ventilation, OLV, and surgical manipulation on diffuse alveolar damage (DAD) after application of different anesthetic regimens. ⋯ TLV resulted in increased DAD scores in the lungs as compared with SB. OLV and thoracic surgery further increased lung injury and leukocyte recruitment independently of the administration of propofol or desflurane anesthesia.