Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth. · Aug 2001
Randomized Controlled Trial Clinical TrialMyocardial lactate production is not involved in the ischemic preconditioning mechanism in coronary artery bypass graft surgery patients.
To study the relationship between ischemic preconditioning (IP) and lactate production and their impact on coronary artery bypass graft surgery patients. ⋯ The IP effects do not include modulation of lactate production. IP induces lactate production, but it seems not to be involved in the triggering process.
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J. Cardiothorac. Vasc. Anesth. · Aug 2001
Endotoxin-neutralizing capacity of serum from cardiac surgical patients.
To determine if endotoxin core antibody (EndoCAb) from the serum of cardiac surgical patients neutralizes endotoxin in an ex vivo biologic assay. ⋯ Anti-EndoCAbs of both classes (IgM and IgG) were able to neutralize lipopolysaccharide from a clinically relevant bacterium in an ex vivo model. Neither Igm nor IgG appeared to be more capable of neutralization in this model. These antibodies did not completely predict neutralization capacity; other endogenous factors in human serum must be capable of lipopolysaccharide neutralization.