Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth.
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J. Cardiothorac. Vasc. Anesth. · Aug 2000
Plasma-soluble E-selectin after cardiopulmonary bypass in children: is it a marker of the postoperative course?
To investigate the relationship and possible role of soluble adhesion molecule E-selectin in the postoperative course in children undergoing cardiopulmonary bypass (CPB). ⋯ These results suggest a relationship between CPB-induced mediators and early and late clinical effects. Although the mechanism for the increase of soluble E-selectin remains to be elucidated, the upregulation of soluble E-selectin indicates neutrophil activation, and its inhibition may represent a target for reducing the inflammatory response associated with CPB.