Nutrition, metabolism, and cardiovascular diseases : NMCD
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Nutr Metab Cardiovasc Dis · Apr 2014
Systemic inflammation is related to coronary microvascular dysfunction in obese patients without obstructive coronary disease.
Obesity, systemic inflammation and changes in the heart functions are associated with increased cardiovascular risk. This study aimed to investigate coronary microvascular dysfunction as an early marker of atherosclerosis in obese patients without any evidence of cardiovascular disease. ⋯ CFR is often reduced in obese subjects without clinical evidence of heart disease, suggesting a coronary microvascular impairment. This microvascular dysfunction seems to be related to a chronic inflammation mediated by adipocytokines. Our findings may explain the increased cardiovascular risk in obesity, independently of BMI.
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Nutr Metab Cardiovasc Dis · Feb 2014
Body mass index, cardiac surgery and clinical outcome. A single-center experience with 9125 patients.
There is evidence for a J-shaped association between Body Mass Index (BMI) and all-cause mortality in general populations. In cardiac surgical patients, the effect of BMI on mortality and major adverse cardiac and cerebrovascular events (MACCE) is not completely clear. ⋯ Data demonstrate that both severe obesity and underweight are independent risk factors for operative complications in cardiac surgical patients. With respect to mid-term survival, special attention should be paid to underweight patients scheduled for cardiac surgery.
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Nutr Metab Cardiovasc Dis · Feb 2014
Comparative StudyComparisons of spot vs 24-h urine samples for estimating population salt intake: validation study in two independent samples of adults in Britain and Italy.
To assess the reliability and reproducibility of estimations of group mean 24-h urinary sodium (Na) excretion through timed spot urines compared to 24 h urinary Na output in two independent cross-sectional population samples including men and women and different ethnic groups. ⋯ Based on these results, 24-h urinary collection for the measurement of Na excretion remains the preferred tool for assessing salt intake when compared with reported methods based on timed spot urine samples.
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Nutr Metab Cardiovasc Dis · Dec 2013
Randomized Controlled TrialImpact of buttermilk consumption on plasma lipids and surrogate markers of cholesterol homeostasis in men and women.
Sphingolipids (SL) are important components of the milk fat globule membrane (MFGM) found in buttermilk. While studies in animal models suggest that dietary SL may have cholesterol-lowering properties, data in human are lacking. The aim of this study was to investigate the impact of buttermilk consumption on plasma lipids and surrogate markers of cholesterol (C) homeostasis in humans. ⋯ This trial is registered at clinicaltrials.gov as NCT01248026.
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Nutr Metab Cardiovasc Dis · Nov 2013
Multicenter Study Clinical TrialPrimary prevention with statins and incident diabetes in hypertensive patients at high cardiovascular risk.
The ESC/ESH guidelines for arterial hypertension recommend using statins for patients with high cardiovascular (CV) risk for both secondary and primary prevention. A recent meta-analysis, combining previous studies on statins, concluded that they are associated with a 9% increased risk of incident type 2 diabetes mellitus (DM). There is no information on whether statins increase incidence of DM in primary prevention. ⋯ In real-life outpatient environment, statin prescription for primary prevention is not associated with increased risk of incident DM.