International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
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Int. J. Gynecol. Cancer · May 2012
Preoperative enoxaparin is safe to use in major gynecologic surgery for prophylaxis of venous thromboembolism: a retrospective cohort study.
To evaluate the safety of preoperative enoxaparin in patients undergoing major gynecologic oncology surgery. ⋯ The use of preoperative enoxaparin is not associated with increased blood loss, transfusion requirements, operative time, or hospital stay among patients having major gynecologic surgery.
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Int. J. Gynecol. Cancer · May 2012
Nerve-sparing class III-IV radical hysterectomy: urodynamic study and surgical technique.
The aim of this study was to demonstrate the impact of the nerve-sparing radical hysterectomy on the bladder function. ⋯ The separation of the hypogastric nerve from the parametrium is a feasible surgical step, which can be implemented in the radical hysterectomy technique in different clinical settings. The comparative urodynamic study showed a mild functional impairment in the early postoperative period. The most frequent finding was the reduced detrusor activity observed during the voiding phase, consistent with the straining needed to void reported in the questionnaire. These data suggest that a mild bladder impairment occurs despite the conservation of the hypogastric nerve.
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Int. J. Gynecol. Cancer · Mar 2012
ReviewAntiangiogenic agents in combination with chemotherapy for the treatment of epithelial ovarian cancer.
The purpose of this review was to provide an overview of angiogenesis, including the rationale for targeting angiogenesis as a treatment strategy for epithelial ovarian cancer (EOC) and to discuss available clinical trial data with antiangiogenic agents in EOC, with a focus on combinations with chemotherapy. ⋯ Results from recently completed and ongoing clinical trials combining antiangiogenic agents with chemotherapy are awaited in hopes of expanding therapeutic options for patients with EOC.