Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
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J Stroke Cerebrovasc Dis · Jun 2015
Multicenter StudySymptomatic intracerebral hemorrhage after intravenous thrombolysis in chinese patients: comparison of prediction models.
To assess the performance of risk scores in predicting symptomatic intracranial hemorrhage (SICH) after intravenous thrombolysis (IVT). ⋯ SITS-SICH, GRASPS, and MSS scores predicted the risk of SICH after IVT in patients with AIS, but only the latter 2 were better in the Chinese population. MSS score had the best predictive performance for SICH using NINDS and ECASS-II definitions, whereas GRASPS score was the best for SICH using the SITS-MOST definition.
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J Stroke Cerebrovasc Dis · Jun 2015
Circulatory and Respiratory Parameters during Acute Endovascular Stroke Therapy in Conscious Sedation or General Anesthesia.
Whether patients suffering from acute ischemic stroke and undergoing endovascular recanalization should be treated under general anesthesia (GA) or conscious sedation (CS) is a matter of debate. According to retrospective studies, GA appears to be associated with a worse outcome than CS. The underlying mechanisms are unknown, but hypotension and hypocapnia during GA have been suggested. There are no prospective data on this question. ⋯ In this small prospective study, patients under CS required less vasopressor medication and had a higher mean blood pressure than those under GA, but they also showed signs of hyperventilation. The impact of these physiological differences on outcome needs to be studied in randomized trials.
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J Stroke Cerebrovasc Dis · Jun 2015
Susceptibility Vessel Sign for Intra-arterial Thrombus in Acute Posterior Cerebral Artery Infarction.
Susceptibility vessel sign (SVS) on susceptibility-weighted imaging (SWI) has a high sensitivity and specificity to detect the intra-arterial thrombus in anterior circulation stroke. However, SVS has not been evaluated in posterior circulation stroke. ⋯ SWI is more sensitive than MRA for the detection of intraluminal thrombus, especially peripheral one, in patients with acute ischemic stroke of the PCA territory. In addition, irrespective of thrombus location, SWI is significantly superior to CT in detecting thrombus in acute PCA infarction.
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J Stroke Cerebrovasc Dis · Jun 2015
Clot characteristics on computed tomography and response to thrombolysis in acute middle cerebral artery stroke.
Clinical and computer tomography angiography (CTA) correlates of hyperdense middle cerebral artery sign (HMCAS) and dot sign were revisited in patients treated for acute MCA stroke. Temporal evolution of these signs over 24 hours was assessed quantitatively by density (Hounsfield unit [HU]) measurements. ⋯ CTA provides dependable (high sensitivity and specificity) information regarding clot size and location, whereas hyperdense artery signs have low sensitivity and just acceptable specificity levels in this regard. However, the prognostic and diagnostic information generated by the presence of hyperdense artery signs and temporal change in attenuation can be useful in acute stroke settings where CTA is not readily available. Quantitative measures, rather than qualitative evaluation have a higher yield in determination of temporal change of the hyperdensity signs and its possible clinical correlates.
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J Stroke Cerebrovasc Dis · May 2015
Genetic Analysis of RNF213 c.14576G>A Variant in Nonatherosclerotic Quasi-Moyamoya Disease.
Quasi-moyamoya disease (MMD) and MMD (definite MMD) have similar cerebral angiographic features, but whether these related diseases have similar etiology or genetic background remains unclear. Recently, we have reported that the recently identified MMD susceptibility gene variant RNF213 c.14576G>A (rs112735431) was associated with atherosclerotic intracranial major artery stenosis/occlusion. The present study investigated the occurrence of RNF213 c.14576G>A in patients with nonatherosclerotic quasi-MMD. ⋯ Nonatherosclerotic quasi-MMD did not have RNF213 c.14576G>A variant. Moyamoya disease and related diseases might be classified by genetic analysis of the RNF213 c.14576G>A genotype. Further larger studies are required to confirm the present findings.