Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
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J. Physiol. Pharmacol. · Nov 2009
ReviewStatistical analysis of chronic obstructive pulmonary disease exacerbations in clinical studies: expectations and limitations.
Acute exacerbations of chronic obstructive pulmonary disease (COPD) occur more frequently with increasing COPD severity and are associated with increased morbidity, reduced quality of life, and increased risk of mortality. The prevention and assessment of exacerbations, as a clinically and therapeutically relevant parameter, is a central aspect of clinical COPD studies. The aim of this review is to identify pitfalls in the analysis of the parameter of exacerbation and to describe the criteria that need to be considered in the statistical analysis of exacerbation studies.
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The outcome of patients with idiopathic pulmonary fibrosis (IPF), which represents the most common type of idiopathic pulmonary pneumonias, is poor. Breathlessness and coughing are usually progressive and about 50% of he patients die within 3 years after diagnosis. The effect of medical treatment in terms of survival is disappointing. ⋯ The therapy of sleep disorders and sleep disordered breathing in IPF is individual. But in the absence of an effective treatment of IPF, optimization of sleep and life quality by the treatment of sleep disorders seems to be a primary goal. Further studies are needed to determine special sleep-related treatment effects.
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J. Physiol. Pharmacol. · Nov 2009
Comparative StudyLeukotriene B4, 8-iso-prostaglandin F2 alpha, and pH in exhaled breath condensate from asymptomatic smokers.
Long-term cigarette smoking is the major etiological factor for the development of chronic obstructive pulmonary disease (COPD). Airway inflammation and oxidative stress are implicated in the pathogenesis. Biomarkers reflecting these responses could be analyzed in exhaled breath condensate (EBC). ⋯ No significant differences were observed in EBC concentrations of LTB(4) or 8-iso-PGF(2 alpha). The study demonstrates that acidopnea is detectable in otherwise asymptomatic smokers and might precede changes in the level of arachidonic acid metabolites. For pH is considered to be the most validated marker determined in EBC samples, it may be useful for screening asymptomatic individuals for smoking-induced early airway damage.
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J. Physiol. Pharmacol. · Nov 2009
Comparative StudyRelationship between airway wall thickness assessed by high-resolution computed tomography and lung function in patients with asthma and chronic obstructive pulmonary disease.
Airway remodeling in asthma and chronic obstructive pulmonary disease (COPD) results in thickening of bronchial walls and may affect lung function. In the present study we set out to evaluate the relationship between small airway wall thickness and the lung function parameters in patients with asthma and COPD. The study was performed in 10 patients with asthma (4M/6F, the mean age 37+/-13 yr) and 12 patients with COPD (7M/5F, the mean age 57+/-9 yr) with stable, mild to moderate disease. ⋯ The number of pack-years correlated with WA and WT in COPD patients. In conclusion, the study shows that the thickening of airway wall in asthma is reflected by an increase in the indices of air trapping and in COPD this thickening results in a higher airway resistance and responsiveness. In COPD, the thickening of airway wall also is related to exposure to tobacco smoke.
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J. Physiol. Pharmacol. · Jun 2009
Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS).
To enhance analgesia, combination of analgesics drugs of proven efficacy is a strategy which is accompanied by a reduction of adverse effects. The present study was undertaken to characterize the antinociceptive interaction of morphine with different non-steroidal anti-inflammatory drugs (NSAIDs) using isobolographic analysis and the writhing test of mice. One of the possible mechanisms of action of spinally administered morphine with non-steroidal antiinflammatory drugs was investigated using the DOR antagonist naltrindole. ⋯ The findings of the present work suggest that the combinations of opioids and non-steroidal anti-inflammatory drugs have a direct action on spinal processing of the nociceptive information, which may achieved by additional mechanisms independent of prostaglandin synthesis inhibition and/or activation of opioid receptors. The lack of effect of naltrindole to modify the analgesic activity of the combination of opioids and NSAIDs indicates that others pain regulatory systems are involved in this central action. Therefore, these combinations could be a viable alternative to clinical pain management, especially trough multimodal analgesia.