Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
-
Review Meta Analysis
Safety and efficacy of corticosteroids for the treatment of septic shock: A systematic review and meta-analysis.
Septic shock is common and results in significant morbidity and mortality. Adjunctive treatment with corticosteroids is common, but definitive data are lacking. We aimed to determine the efficacy and safety of corticosteroid therapy among patients with septic shock. ⋯ In patients with septic shock, corticosteroid therapy appears to be safe but does not reduce 28-day all-cause mortality rates. It does, however, significantly reduce the incidence of vasopressor-dependent shock, which may be a clinically worthwhile goal.