Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
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Randomized Controlled Trial Clinical Trial
A prospective intervention study on higher-dose oseltamivir treatment in adults hospitalized with influenza a and B infections.
It is unclear if higher-dose oseltamivir provides benefit beyond the standard dose in influenza patients who require hospitalization. ⋯ ClinicalTrials.gov, NCT01052961.
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In this IDSA policy paper, we review the current diagnostic landscape, including unmet needs and emerging technologies, and assess the challenges to the development and clinical integration of improved tests. To fulfill the promise of emerging diagnostics, IDSA presents recommendations that address a host of identified barriers. Achieving these goals will require the engagement and coordination of a number of stakeholders, including Congress, funding and regulatory bodies, public health agencies, the diagnostics industry, healthcare systems, professional societies, and individual clinicians.
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Randomized Controlled Trial Clinical Trial
Iron supplementation in HIV-infected Malawian children with anemia: a double-blind, randomized, controlled trial.
It is unknown whether iron supplementation in human immunodeficiency virus (HIV)-infected children living in regions with high infection pressure is safe or beneficial. A 2-arm, double-blind, randomized, controlled trial was conducted to examine the effects of iron supplementation on hemoglobin, HIV disease progression, and morbidity. ⋯ ISRCTN-62947977.
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Observational Study
Clinical characteristics of Dengue shock syndrome in Vietnamese children: a 10-year prospective study in a single hospital.
Dengue shock syndrome (DSS) is a severe manifestation of dengue virus infection that particularly affects children and young adults. Despite its increasing global importance, there are no prospective studies describing the clinical characteristics, management, or outcomes of DSS. ⋯ With prompt intervention and assiduous clinical care by experienced staff, the outcome of this potentially fatal condition can be excellent.