Paediatric anaesthesia
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Paediatric anaesthesia · Dec 2011
Retraction Of PublicationRetraction. Controversial issues: compartment syndrome, test dose, LOR- air/saline, etc.
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Paediatric anaesthesia · Dec 2011
Randomized Controlled TrialExplaining the acetaminophen-ibuprofen analgesic interaction using a response surface model.
The value of acetaminophen-ibuprofen combination therapy over single therapy is uncertain in acute pediatric pain management. A model describing the interaction between these two drugs would be useful both for understanding current literature and for future study design. ⋯ This drug interaction modeling example is useful to explain combination therapy nuances and impacts on study design. Differences in effect between single drug therapy and combination therapy should be sought at lower doses and beyond the immediate postoperative period. Combination therapy may prolong the duration of analgesia. The maximum effect (E(MAX) ) limits the early additional analgesic gain from combination therapy beyond commonly used doses.
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Paediatric anaesthesia · Dec 2011
ReviewPro con debate: the use of regional vs systemic analgesia for neonatal surgery.
In recent years the inclusion of regional techniques to pediatric anesthesia has transformed practice. Simple procedures such as caudal anesthesia with local anaesthetics can reduce the amounts of general anesthesia required and provide complete analgesia in the postoperative period while avoiding large amounts of opioid analgesia with potential side effects that can impair recovery. ⋯ Currently, opinions are divided and strongly held with some major units adopting this approach widely and others maintaining a more conservative stance to anesthesia for major neonatal surgery. In this pro-con debate the evidence base is examined, supplemented with expert opinion to try to provide a balanced overall view.