Paediatric anaesthesia
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Paediatric anaesthesia · Mar 2015
Clinical TrialSedation monitoring during open muscle biopsy in children by Comfort Score and Bispectral Index - a prospective analysis.
Open muscle biopsies in children are generally performed under general anesthesia. Alternatively, deep sedation and analgesia may be required. ⋯ Bispectral Index provides an additional helpful tool to guide sedation/analgesia in minor surgical procedures in children. BIS values ≤60 correlated with sufficient depth of sedation and prevented unintended awareness. Additionally, BIS measurement allowed for distinct regulation of depth of sedation without prolonged sedation/analgesia due to unintended overdose.
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Paediatric anaesthesia · Mar 2015
Comparative StudyA comparison of functional magnetic resonance imaging findings in children with and without a history of early exposure to general anesthesia.
Functional magnetic resonance imaging (fMRI) has been used to evaluate the long-term consequences of early exposure to neurotoxic agents. fMRI shows that different patterns of brain activation occur in ethanol-exposed subjects performing a go/no-go response inhibition task. Pharmacologically, ethanol and general anesthetics have similar receptor-level activity in the brain. This study utilizes fMRI to examine brain activation patterns in children exposed to general anesthesia and surgery during early brain development. ⋯ Early anesthetic exposure and surgery did not affect accuracy, response time, or activation patterns in the primary region of interest during performance of the task. Intergroup differences in activation patterns in other areas of the brain were observed, and the significance of these findings is unknown. fMRI appears to be a useful tool in evaluating the long-term effects of early exposure to general anesthesia.