Paediatric anaesthesia
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Paediatric anaesthesia · Jan 2013
Editorial Historical ArticleHistory of pediatric anesthesia timeline.
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Paediatric anaesthesia · Jan 2013
Ultrasound detection of guidewires in-plane during pediatric central venous catheterization.
To assess the usefulness of longitudinal ultrasound images of guidewires for pediatric central venous catheter (CVC) placement. ⋯ To confirm the insertion of dilators into veins in children, we recommend that longitudinal images of the guidewires should be initially acquired.
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Paediatric anaesthesia · Jan 2013
The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion.
The optimal methadone dosing regimen for children undergoing spinal surgery is uncertain because of sparse pediatric pharmacokinetic data and a paucity of analgesic effect data. The minimum effective analgesic concentration of methadone in opioid naïve adults is 58 mcg · L(-1). ⋯ Current pharmacokinetic parameter estimates in adolescents are similar to those reported in adults. Methadone undergoes rapid redistribution after bolus administration. This may result in plasma concentrations that provide inadequate analgesia postoperatively. We would suggest following the bolus (0.25 mg.kg(-1)) with an infusion (0.1-0.15 mg · kg(-1) · h(-1) for 4 h) during spinal surgery to ensure adequate plasma concentrations for 24 h.