Paediatric anaesthesia
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Paediatric anaesthesia · Nov 2007
Maturational pharmacokinetics of single intravenous bolus of propofol.
Our aim was to document propofol pharmacokinetics in preterm and term neonates following a single intravenous bolus and compare these estimates with pharmacokinetics findings in toddlers and young children. ⋯ Propofol disposition is significantly different in neonates compared with toddlers and young children, reflecting both ontogeny and differences in body composition. Based on the reduced clearance of propofol, a longer recovery time is more likely to occur in neonates.
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Paediatric anaesthesia · Nov 2007
Case ReportsLong-term use of an intravenous ketamine infusion in a child with significant burns.
We report the use of an intravenous ketamine infusion for 37 days in a 9-year-old child with 42% body surface area burns. Ketamine was administered both in the intensive care unit and the surgical ward and provided high quality analgesia as an opioid adjunct. ⋯ This case demonstrates the safe and effective use of long-term intravenous ketamine in a child with significant burns on a surgical ward. We have focused the discussion on the issues of tolerance and weaning of long-term ketamine infusions in children.