Pharmacoepidemiology and drug safety
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Pharmacoepidemiol Drug Saf · Jan 2000
A retrospective study to determine if hydroxyurea augmentation of antiretroviral drug regimens that contain ddI and/or d4T increases the risk of developing peripheral neuropathy in HIV-1 infected individuals.
To determine if hydroxyurea augmentation of antiretroviral drug regimens that contain ddI and/or d4T increases the risk of developing peripheral neuropathy in HIV-1 infected individuals. In addition, to determine predictors of peripheral neuropathy occurrence in HIV-1 infected individuals who are on a ddI- and/or d4T-containing antiretroviral drug regimen. ⋯ These findings suggest that hydroxyurea augmentation of a ddI- and/or d4T-containing antiretroviral drug regimen may increase the risk of peripheral neuropathy occurrence in HIV-1 infected patients. Copyright (c) 2000 John Wiley & Sons, Ltd.
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The association between patterns of use of benzodiazepines and chronic somatic morbidity was examined by applying the Chronic Disease Score (CDS). In the only pharmacy in a Dutch community, 6921 patients with data available covering a 10-year period (1983-1992) were included. In 1992, two-thirds of the patients had a CDS of 0, indicating no chronic morbidity. ⋯ Moreover, a history of benzodiazepine use was found to predict a sharp increase in chronic morbidity. We found a clear association between previous and actual use of benzodiazepines and chronic somatic disease. Benzodiazepine use may be induced by sleeping difficulties and anxiety problems caused by the chronic disease.