Cell transplantation
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Cell transplantation · Jan 1995
ReviewRecent topics in the management of pain: development of the concept of preemptive analgesia.
Recent studies concerned with the relationship between injury responses and acute and chronic pain were reviewed. Basic and clinical studies of pain have revealed that a large proportion of the mechanisms that produce strange signs and symptoms, such as allodynia, hyperalgesia and hyperpathia, after tissue injury are ascribed to increased excitability, or to sensitization derived from biological changes in spinal dorsal horn cells subjected to excessive noxious stimuli from injured tissues. ⋯ The findings of many clinical investigations, however, remain controversial. This report discusses the importance of preemptive analgesia including the possibilities of prevention, and of extension to the control, of chronic pain syndromes.
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Cell transplantation · Mar 1993
Clinical TrialResults of a triple blind clinical study of myoblast transplantations without immunosuppressive treatment in young boys with Duchenne muscular dystrophy.
The effects of myoblast transplantations without an immunosuppressive treatment on muscle strength, and the formation of dystrophin-positive fibers was studied in five young boys with Duchenne muscular dystrophy (DMD) using a triple blind design. Injections of myoblasts were made into one biceps brachii (BB), and the opposite BB, used as a control, was sham-injected; the experimenters and the patient were blind to the myoblast-injected side. At the same time, myoblasts were also injected in the left tibialis anterior (TA) of these patients. ⋯ Antibodies were capable of fixing the complement, and of lysing the newly formed myotubes. One of the antigens recognized by this immune response is possibly dystrophin. These results strongly suggest that myoblast transplantations, as well as gene therapy for DMD, cannot be done without immunosuppression.