American journal of ophthalmology
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To report a series of 4 recurrent orbital varices after resection, 2 of which were embolized with cyanoacrylate glue before surgery. ⋯ Orbital varices may be recurrent, even after n-butyl cyanoacrylate embolization, with repeated Valsalva-type maneuvers.
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Randomized Controlled Trial Multicenter Study Comparative Study
Randomized controlled trial of intravitreal ranibizumab versus standard grid laser for macular edema following branch retinal vein occlusion.
To assess the efficacy of intravitreal 0.5 mg ranibizumab for the treatment of center-involving macular edema secondary to branch retinal vein occlusion (BRVO) over 1 year compared with standard-of-care grid laser. ⋯ Compared with standard grid laser, intravitreal ranibizumab provided significant and sustained benefits in visual acuity gain and anatomic improvement in eyes with macular edema secondary to BRVO.
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Randomized Controlled Trial
Teaching ophthalmoscopy to medical students (the TOTeMS study).
To determine medical student preferences for learning the ocular fundus examination and to assess their accuracy using different examination modalities. ⋯ Students preferred fundus photographs for both learning and examining the ocular fundus. Identification of ocular fundus features was more accurate on photographs compared to examination by direct ophthalmoscopy. In the future, the increasing availability of nonmydriatic ocular fundus photography may allow replacement of direct ophthalmoscopy in many clinical settings for non-ophthalmologists.
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To review what progress has been made towards the application of ocular gene therapy to prevent progressive vision loss in patients affected by choroideremia. ⋯ Whereas the time frame for the development of therapies for some retinal dystrophies may be in the years hence, gene therapy trials for choroideremia have started in the United Kingdom and results are pending. These first trials may help resolve the remaining issues associated with the treatment of this disease.
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Randomized Controlled Trial Comparative Study
A prospective randomized trial of intravitreal bevacizumab versus ranibizumab for the management of diabetic macular edema.
To compare visual acuity and spectral-domain optical coherence tomography (SDOCT) outcomes associated with intravitreal (IV) bevacizumab vs IV ranibizumab for the management of diabetic macular edema (DME). ⋯ IV bevacizumab and IV ranibizumab are associated with similar effects on central subfield thickness in patients with DME through 1 year of follow-up. IV ranibizumab is associated with greater improvement in BCVA at some study visits, and the mean number of injections is higher in the IV bevacizumab group.