Neuroimaging clinics of North America
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Neuroimaging Clin. N. Am. · Feb 2018
ReviewDefinition of Traumatic Brain Injury, Neurosurgery, Trauma Orthopedics, Neuroimaging, Psychology, and Psychiatry in Mild Traumatic Brain Injury.
Traumatic brain injury (TBI) disrupts the normal function of the brain. This condition can adversely affect a person's quality of life with cognitive, behavioral, emotional, and physical symptoms that limit interpersonal, social, and occupational functioning. ⋯ Patients with TBI require prompt evaluation and multidisciplinary management. Aside from the type and severity of the TBI, recovery is influenced by individual patient characteristics, social and environmental factors, and access to medical and rehabilitation services.
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Neuroimaging Clin. N. Am. · Feb 2018
ReviewSusceptibility-Weighted Imaging and Magnetic Resonance Spectroscopy in Concussion.
Although susceptibility-weighted imaging (SWI) studies have suggested an increased number of microhemorrhages in concussion, most show no significant differences compared with controls. There have been mixed results on using SWI to predict neurologic outcomes. ⋯ Applications in individual patients are impeded by conflicting data and lack of consensus on an optimal protocol. Therefore, currently MRS has most utility in group-level comparisons designed to reveal the pathophysiology of concussion.
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Neuroimaging Clin. N. Am. · Nov 2017
ReviewApplication of Resting State Functional MR Imaging to Presurgical Mapping: Language Mapping.
Resting state functional MR imaging (rs-fMR imaging) has become an indispensable tool for examining brain function. The greatest opportunity to translate rs-fMR imaging from the research domain into clinical use is as a tool for examining intrinsic brain networks for preoperative planning. Many studies have demonstrated concordance of intrinsic motor networks from rs-fMR imaging data with task-fMR imaging and direct cortical stimulation. Earlier reports show concordance of language networks as well, although more recent studies with larger numbers of subjects demonstrate subject-level variability that needs to be further investigated and addressed before widespread implementation of rs-fMR imaging for preoperative planning.
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Neuroimaging Clin. N. Am. · Nov 2017
ReviewApplications of Resting-State Functional Connectivity to Neurodegenerative Disease.
Neurodegenerative diseases target specific large-scale neuronal networks, leading to distinct behavioral and cognitive dysfunctions. Resting-state functional magnetic resonance imaging (rsfMR imaging)-based functional connectivity method maps symptoms-associated functional network deterioration in vivo. ⋯ Understanding of disease mechanism can further guide early detection and predictions of disease progression and inform development of more effective treatment. With better clinical phenotyping and larger samples across multiple sites, we discuss several possible future directions to further develop rsfMR imaging-based functional connectivity methods into scientifically and clinically useful assays for neurodegenerative disorders.
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Neuroimaging Clin. N. Am. · Nov 2017
ReviewTen Key Observations on the Analysis of Resting-state Functional MR Imaging Data Using Independent Component Analysis.
For more than 20 years, the powerful, flexible family of independent component analysis (ICA) techniques has been used to examine spatial, temporal, and subject variation in functional magnetic resonance (fMR) imaging data. This article provides an overview of 10 key principles in the basic and advanced application of ICA to resting-state fMR imaging. ICA's core advantages include robustness to artifact; false-positives and autocorrelation; adaptability to variant study designs; agnosticism to the temporal evolution of fMR imaging signals; and ability to extract, identify, and analyze neural networks. ICA remains in the vanguard of fMRI methods development.