The American journal of the medical sciences
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Podocytes play an important role in the pathogenesis and progression of glomerulosclerosis. Various elements of the renin-angiotensin-aldosterone system can induce podocyte apoptosis. However, little is known about the direct effects of renin on podocytes. ⋯ The authors conclude that the effects of renin are mediated through the activation of rennin receptor and are independent of angiotensin II generation.