The American journal of the medical sciences
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Although inhibitors of the proto-oncogene BRAF have shown excellent antitumor activity against malignant melanoma, their efficacy is limited by the development of acquired drug resistance, a process in which reactivation of MAP kinase (MEK) is known to play an important role. In this study, we evaluated the efficacy of AS703026, a new MEK inhibitor, in BRAF inhibitor-resistant melanoma cell lines. ⋯ Our results suggest that combined treatment with AS703026 and a BRAF inhibitor overcomes the resistance to BRAF inhibitors in malignant melanoma cells harboring a mutant form of BRAF.
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Screening for and treatment of latent tuberculosis infection (LTBI) have been essential components of the TB elimination strategy. ⋯ The current rate of reactivation TB in Texas is much lower than rates reported in the United States in the 1950s. Certain patients are at increased risk for reactivation and should be monitored more closely during LTBI therapy.