The American journal of the medical sciences
The most recent articles from:
Am. J. Med. Sci.
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Letter Case Reports
An Uncommon Cause of Ring-Enhancing Brain Lesion: Cerebral Aspergillosis.
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Letter Case Reports
Chocolate milk in CRRT circuit: Propofol induced hypertriglyceridemia.
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Despite anti-retroviral therapy, HIV-1 infection increases the risk of pneumonia and causes oxidative stress and defective alveolar macrophage (AM) immune function. We have previously determined that HIV-1 proteins inhibit antioxidant defenses and impair AM phagocytosis by suppressing nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Given its known effects on Nrf2, we hypothesize miR-144 mediates the HIV-1 induced suppression of Nrf2. ⋯ Our results suggest that inhibiting miR-144 or interfering with its deleterious effects on Nrf2 attenuates HIV-1-mediated AM immune dysfunction and improves lung health in individuals with HIV.