The American journal of the medical sciences
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Letter Case Reports
Pancreatic Fibroma: A Rare Cause of Intraperitoneal Hemorrhage.
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Review Case Reports
Endemic and emerging coronavirus pulmonary infections.
Coronaviruses are a well-known cause of upper and lower respiratory disease, and since 2002 have been a recognized source of potential pandemic spread. Over the past two decades, since the Severe Acute Respiratory Syndrome (SARS) outbreak, a large body of research has accumulated on the virology, clinical symptoms and signs, and experimental treatments of Coronaviruses. In 2020, a new form of Coronaviruses (SARS-CoV-2) emerged and spread rapidly throughout the globe. ⋯ Furthermore, due to suboptimal testing capabilities, an early clinical diagnosis is not always possible. Here, we present a case of a patient with pneumonia thought to be caused by SARS-CoV-2 only to be found to have another Coronavirus. This emphasizes the need to be vigilant when evaluating patients with viral-like respiratory infections.
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Obesity and overweight are the most prevailing problem in most countries. Overweight people are very susceptible to diseases such as diabetes, hypertension, cardiovascular disease, metabolic syndrome, and cancers. Adequate intake of micronutrients along with a quality diet that is varied and balanced plays an important role regarding health and the immune system. Numerous studies have investigated the relationship between the quality of diet and different diseases. Genetics is a risk factor of great importance regarding obesity and overweight. Yet, the role of nutrition in relationship with the underlying mechanisms remains unclear and no specific pathways have been identified for this relation. ⋯ Intake of vitamin D from sunlight and its nutritional sources and adequate intake of Mn from a wide range of vegetables, legumes, seeds, and grains might be solutions for some overweight cases with FTO rs9939609 polymorphism.
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus responsible for the coronavirus disease -19 (COVID-19). Since December 2019, SARS-CoV-2 has infected millions of people worldwide, leaving hundreds of thousands dead. Chloroquine (CQ) and Hydroxychloroquine (HCQ) are antimalarial medications that have been found to have in vitro efficacy against SARS-CoV-2. ⋯ Appropriate dose and duration of therapy are unknown. Here, we will discuss the pharmacokinetic and pharmacodynamic properties of CQ and HCQ, as well as review the antiviral properties. The manuscript will also examine the available data from recent clinical and preclinical trials in order to shed light on the apparent inconsistencies.