Transfusion medicine
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Transfusion medicine · Aug 2013
Association of age and packed red blood cell transfusion to 1-year survival--an observational study of ICU patients.
To compare the 1-year survival for different age strata of intensive care unit (ICU) patients after receipt of packed red blood cell (PRBC) transfusions. ⋯ We found no significant interaction between receipt of red cell transfusion and age, as variables, and survival at 1 year as an outcome.
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Transfusion medicine · Apr 2013
Comparative Study Clinical TrialExperience with a massive transfusion protocol in the management of massive haemorrhage.
A massive transfusion response (MTR) was introduced in 2007 to provide blood and blood products in a timelier manner. Aim of this study was to determine whether implementation of the MTR was associated with a change in clinical practice or mortality. ⋯ Although there has been a significant change in transfusion practice in MT patients using a MTR, no change in mortality could be documented using such a protocol.
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Transfusion medicine · Dec 2012
ReviewThe evidence for the use of recombinant factor VIIa in massive bleeding: revision of the transfusion policy framework.
In 2006, the Canadian National Advisory Committee on Blood and Blood Products (NAC) developed a transfusion policy framework for the use of off-label recombinant factor VIIa (rFVIIa) in massive bleeding. Because the number of randomised controlled trials has doubled, the NAC undertook a review of the policy framework in 2011. ⋯ Contrarily, an increase in arterial thromboembolic events has been observed with the use of off-label rFVIIa. Given the absence of evidence of benefit and with evidence of the risk of harm, the NAC recommends that recombinant VIIa no longer be used for the off-label indications of prevention and treatment of bleeding in patients without haemophilia.
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Transfusion medicine · Dec 2012
Randomized Controlled TrialIntraoperative transfusion threshold and tissue oxygenation: a randomised trial.
Transfusion with allogeneic red blood cells (RBCs) may be needed to maintain oxygen delivery during major surgery, but the appropriate haemoglobin (Hb) concentration threshold has not been well established. We hypothesised that a higher level of Hb would be associated with improved subcutaneous oxygen tension during major spinal surgery. ⋯ A Hb concentration transfusion threshold of 8·9 g dL(-1) was not associated with a higher subcutaneous oxygen tension during major spinal surgery than a threshold of 7·3 g dL(-1), but the trial was compromised by methodological difficulties.