European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
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Intervertebral disk (IVD) lesion and its subsequent degeneration have a profound effect on the multifidus muscle. The subacute/early chronic phase of multifidus remodeling after IVD lesion has been proposed to be regulated by inflammatory processes. The balance between pro-inflammatory (M1) and anti-inflammatory (M2) macrophages plays an important role in maintaining tissue integrity after injury. The localization, polarization of macrophage subtypes and their mediation of the pro-inflammatory cytokine tumor necrosis factor (TNF) are unknown in paraspinal muscles during IVD degeneration. A sheep model of IVD degeneration was used to investigate the role of macrophages and TNF in the structural alterations that occur within the multifidus muscle. ⋯ These data support the proposal that macrophages and TNF (pro-inflammatory cytokine) play an active role in the subacute/early chronic phase of remodeling in muscle, adipose and connective tissues of the multifidus during IVD degeneration. This presents a novel target for treatment. These slides can be retrieved under Electronic Supplementary Material.
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Instrumentation of the lumbar spine is a common procedure for treating pathologic conditions. Studies have revealed the risks of pathologies in the adjacent segments, with the incidence rate being up to 36.1%. Revision procedures are often required, including extension of the instrumentation by the use of connectors to adjacent levels. The aim of this study was to determine the stiffness of side-to-side and end-to-end connectors for comparison with the use of continuous rods. ⋯ From a biomechanical viewpoint, the tested connectors are comparable to continuous rods in terms of ROM and NZ. These slides can be retrieved under Electronic Supplementary Material.