European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
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Rib cage deformity is an important component of scoliosis, but few authors have reported the three-dimensional (3-D) effect of surgical procedures with posterior instrumentation systems on the shape of the rib cage. The objective of this prospective clinical study was to measure the short-term 3-D changes in the shape of the rib cage at the apex of the curve after corrective surgery of adolescent idiopathic scoliosis by a posterior approach using a multi rod, hook and screw system. The 3-D shape of the spine and rib cage was modelled pre- and postoperatively using a 3-D reconstruction technique based on multi-planar radiography in a group of 29 adolescents with idiopathic scoliosis. ⋯ The frontal spinal curve correction averaged 53% in the frontal plane, while no significant change was noted in the sagittal plane. Significant changes were noted in the shape of the rib cage: rib hump at the apex and at the adjacent lower level were improved (36% and 38%), and small but significant differences were detected in rib frontal orientation in the concavity of the curves at the apex and adjacent lower rib levels. Multi rod, hook and screw instrumentation systems, such as Cotrel-Dubousset instrumentation, are effective in producing significant improvements in the 3-D shape of the rib cage, but these changes are less important than those observed at the spine level.
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The purpose of the present study was to introduce a new magnetic resonance imaging (MRI) procedure showing the whole spine in a coronal and sagittal plane, and to study the assessment of sagittal Cobb angle measurements using this technique. Prospectively we studied 32 patients (average age 14.8 years) with idiopathic scoliosis (mean thoracic Cobb angle 33 degrees on radiograph) and 18 patients (average age 14.5 years) without scoliosis. The MRI investigation was carried out in a standard supine position. ⋯ MR total spine imaging makes it possible to image scoliosis in the sagittal plane. On these MR projections, idiopathic thoracic scoliosis was identified by a reduced sagittal Cobb angle. MR total spine imaging would allow monitoring of scoliosis in the sagittal plane, which can reveal relevant clinical data without radiation exposure.
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Transforming growth factor beta (TGF-beta) is a potent inducer of angiogenesis and fibrogenesis. There is presently little information about the pathophysiological function of TGF-beta in herniated disc tissue. In order to analyze the cellular role and activation of TGF-beta after disc herniation we immunostained frozen material from 38 disc herniation operations and from eight macroscopically normal discs from organ donors. ⋯ For all three antibodies, a statistically significantly (Mann-Whitney test, P = 0.0001) higher number of disc cells showed immunopositivity in the herniated discs. The increase in TGF-beta receptor immunopositivity suggested induction of TGF-beta receptors in herniated discs. Our results support an active regulatory role for TGF-beta in disc cell metabolism.