Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
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Support Care Cancer · Dec 2017
Multicenter Study Observational StudyMulticenter, cross-sectional observational study of the impact of neuropathic pain on quality of life in cancer patients.
Neuropathic cancer pain (NCP) is a common and potentially debilitating symptom in cancer patients. We investigated the prevalence of NCP, as well as its management and association with QOL. ⋯ We found that NCP in cancer patients was significantly associated with a worsened QOL, and current management is inadequate. Therefore, future research aimed at developing improved strategies for management of NCP is required.
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Support Care Cancer · Nov 2017
Psychometric testing of the Mandarin version of the 34-item Short-Form Supportive Care Needs Survey in patients with cancer in mainland China.
Although the Supportive Care Needs Survey is one of the most comprehensive and robust cancer-specific needs assessment instruments, no version exists specifically for cancer patients in mainland China. This study tested the psychometric properties of the Mandarin version of the 34-item Short-Form Supportive Care Needs Survey (SCNS-SF34-C (Mandarin)) in mainland Chinese cancer patients. ⋯ Preliminary evidence suggests that the SCNS-SF34-C (Mandarin) is a reliable and valid instrument for assessing the supportive care needs of cancer patients in mainland China.
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Support Care Cancer · Nov 2017
Randomized Controlled Trial Multicenter StudyA pilot study of minocycline for the prevention of paclitaxel-associated neuropathy: ACCRU study RU221408I.
Paclitaxel is associated with both an acute pain syndrome (P-APS) and chronic chemotherapy-induced peripheral neuropathy (CIPN). Given that extensive animal data suggest that minocycline may prevent chemotherapy-induced neurotoxicity, the purpose of this pilot study was to investigate the efficacy of minocycline for the prevention of CIPN and the P-APS. ⋯ Results of this pilot study do not support the use of minocycline to prevent CIPN, but suggest that it may reduce P-APS and decrease fatigue; further study of the impact of this agent on those endpoints may be warranted.
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Support Care Cancer · Nov 2017
ReviewOptimal clinical assessment strategies for chemotherapy-induced peripheral neuropathy (CIPN): a systematic review and Delphi survey.
Chemotherapy-induced peripheral neuropathy (CIPN) is a prominent side effect of the treatment of cancer. Despite this frequent complication, there has been no comprehensive review and quality appraisal of CIPN assessments. The purpose of this study is to provide a definitive quality appraisal of CIPN assessment strategies for clinical use. ⋯ A diverse range of CIPN assessments currently exists. While several assessments assess CIPN symptoms with adequate comprehensiveness, depth, language, and feasibility, the consensus 'gold standard' clinical assessment remains to be established.
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Support Care Cancer · Nov 2017
Timing to antibiotic therapy in septic oncologic patients presenting without hypotension.
Sepsis accounts for only 2% of the hospitalizations worldwide but more than 17% of total in-hospital mortality. Inappropriate antimicrobial selection and delays in appropriate therapy have been associated with reduced survival in severe sepsis and septic shock. No studies to date have exclusively targeted septic oncologic patients without hypotension. ⋯ Time to appropriate antibiotics and in-hospital mortality were associated in this population of adult oncologic patients with sepsis without hypotension. Clinicians in the emergency department should strive to ensure the timely administration of a complete and appropriate empiric antibiotic regimen in septic patients with active cancer even in the absence of hypotension.