Current opinion in nephrology and hypertension
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Curr. Opin. Nephrol. Hypertens. · Mar 2007
ReviewTreatment of acute kidney injury: an update on the management of renal replacement therapy.
Renal replacement therapy remains the cornerstone of management for the patient with severe acute kidney injury. Although the technology for providing renal replacement therapy has markedly advanced over the past few decades, fundamental issues regarding its management, including timing of initiation, selection of modality and dosing of therapy, remain unresolved. ⋯ The optimal management of renal replacement therapy in patients with acute kidney injury remains uncertain. Appropriately designed studies evaluating timing of initiation of therapy need to be undertaken. Current data suggest that modality of therapy does not impact outcome. More intensive renal support may be associated with improved outcomes; however several large randomized controlled trials assessing this question are ongoing.
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Curr. Opin. Nephrol. Hypertens. · Mar 2006
Review Comparative StudyCardiovascular disease in the dialysis population: prognostic significance of arterial disorders.
Cardiovascular disease is a major factor in the high mortality of patients with end-stage renal disease, and this population is particularly appropriate to analyse the impact of cardiovascular risk markers on outcome. ⋯ Aortic stiffness measurements could serve as an important tool in identifying end-stage renal disease patients at higher risk of cardiovascular disease. The ability to identify these patients would lead to better risk stratification and earlier and more cost-effective preventive therapy.
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Curr. Opin. Nephrol. Hypertens. · Sep 2005
ReviewNa+/H+ exchangers: physiology and link to hypertension and organ ischemia.
Na/H exchangers (NHEs) are ubiquitous proteins with a very wide array of physiological functions, and they are summarized in this paper in view of the most recent advances. Hypertension and organ ischemia are two disease states of paramount importance in which NHEs have been implicated. The involvement of NHEs in the pathophysiology of these disorders is incompletely understood. This paper reviews the principal findings and current hypotheses linking NHE dysfunction to hypertension and ischemia. ⋯ This paper provides the interested reader with a concise overview of NHE physiology, and aims to address the implication of NHEs in the pathophysiology of hypertension and organ ischemia in light of the most recent literature.
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Curr. Opin. Nephrol. Hypertens. · Mar 2005
ReviewGenomics, proteomics and integrative "omics" in hypertension research.
During the past few years, genomics, proteomics and other "omics" fields have been applied extensively to several areas of biomedical research. This review provides an overview and summarizes the current status of applications of these omics fields to essential and secondary hypertension. Some perspectives of these fields for future hypertension research are discussed. ⋯ Genomics, proteomics and integrative omics have demonstrated their potential in hypertension research to better understand the pathogenesis and pathophysiology of hypertension. In addition, they may contribute to identification of new therapeutic targets, biomarker discovery, prediction of therapeutic response, personalized treatment regimens, better therapeutic outcome and ultimately prevention of the disease.