Addiction
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Cannabis is one of the most widely used drugs throughout the world. The psychoactive constituent of cannabis, delta 9-tetrahydrocannabinol (delta 9-THC), produces a myriad of pharmacological effects in animals and humans. For many decades, the mechanism of action of cannabinoids, compounds which are structurally similar to delta 9-THC, was unknown. ⋯ However, cannabinoid-derived drugs on the market today lack specificity and produce many unpleasant side effects, thus limiting therapeutic usefulness. The advent of highly potent analogs and a specific antagonist may make possible the development of compounds that lack undesirable side effects. The advancements in the field of cannabinoid pharmacology should facilitate our understanding of the physiological role of endogenous cannabinoids.
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Comparative Study
Comparisons of alcohol and other drugs: experience from the WHO Collaborative Cross-Cultural Applicability Research (CAR) Study.
Current psychiatric classificatory systems commonly provide similar criteria for the identification of disorders relating to the use of alcohol and other drugs. However, since cultural views of substance use disorders are influenced by prevailing norms in the society, it is unlikely that a given culture will have identical threshold for the identification of disorders relating to the use of alcohol, commonly socially approved, and those relating to the use of other mood-altering substances, commonly socially disapproved. ⋯ Our observations suggest that, with a few notable exceptions, any use of addictive substances other than alcohol is commonly considered socially aberrant. Most cultures set a much lower threshold for the identification of disorders relating to these substances than they do for alcohol-related ones.
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Comparative Study
The analysis of policy: understanding the process of policy development.
A key question in addiction studies is why do governments not readily adopt policies that research shows to be effective in reducing harm? In this paper, it is argued that policy development can best be understood as a political activity, which is not necessarily scientific. A descriptive model of policy analysis is illustrated by case examples from alcohol and tobacco policy arenas. By understanding policy development as a process, it is suggested that policy advocates can match their strategies to the stages of the process, and thus raise the probability that the advocated policy will be adopted.