Osteoarthritis and cartilage
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Osteoarthr. Cartil. · Sep 2007
Cross-cultural adaptation and validation of Singapore English and Chinese Versions of the Oxford Knee Score (OKS) in knee osteoarthritis patients undergoing total knee replacement.
To cross-culturally adapt and validate Singapore English and Chinese versions of the Oxford Knee Score (OKS) in patients with knee osteoarthritis (OA) undergoing total knee replacement (TKR) surgery. ⋯ Singapore English and Chinese OKS demonstrated good patient acceptability and psychometric properties (including construct validity) among multiethnic Asian patients with knee OA undergoing TKR.
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Osteoarthr. Cartil. · Sep 2007
Health-related quality of life in patients with osteoarthritis after total knee replacement: factors influencing outcomes at 36 months of follow-up.
(1) To evaluate health-related quality of life (HRQL) in patients with severe osteoarthritis (OA) undergoing total knee replacement (TKR) and (2) to identify the influence of sociodemographic, clinical, intra-operative and postoperative variables on HRQL at 36 months after TKR. ⋯ In patients with severe OA, HRQL significantly improved at 36 months after TKR, especially in the pain dimension. Lower preoperative WOMAC scores, chronic pain unrelated to knee OA, and severe obesity negatively influenced postoperative WOMAC scores. This disease-specific questionnaire may help to identify patients at increased risk of negative outcomes after surgery.
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Osteoarthr. Cartil. · Aug 2007
Randomized Controlled Trial Multicenter Study Comparative StudyAceclofenac vs paracetamol in the management of symptomatic osteoarthritis of the knee: a double-blind 6-week randomized controlled trial.
To evaluate the efficacy and tolerability of aceclofenac, 200 mg/day, and paracetamol, 3000 mg/day, in the treatment of osteoarthritis (OA) of the knee. ⋯ At 6 weeks, patients with symptomatic OA of the knee showed a greater improvement in pain and functional capacity with aceclofenac than paracetamol with no difference in tolerability.
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Osteoarthr. Cartil. · Aug 2007
Review Meta AnalysisEfficacy and safety of opioids for osteoarthritis: a meta-analysis of randomized controlled trials.
To determine the analgesic effectiveness, the effect on physical function and the safety of opioids in patients with osteoarthritis (OA). ⋯ Opioids significantly decrease pain intensity and have small benefits on function compared with placebo in patients with OA. Adverse events, although reversible and not life threatening, often cause participants to stop taking the medication and could limit opioid usefulness. Moreover, the long-term efficacy and safety of these drugs for OA is yet to be determined due to the short mean trial duration.
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Osteoarthr. Cartil. · Jul 2007
Changes in pain, stiffness and physical function in patients with osteoarthritis waiting for hip or knee joint replacement surgery.
Little has been reported on changes in health status in patients with osteoarthritis (OA) while waiting for hip or knee replacement surgery. In this study we assessed (1) changes in self-reported pain, stiffness and physical function in patients with OA of the hip or knee, from the decision to undergo surgery to 14 days prior to surgery, and (2) the determinants of these changes. ⋯ Patients with OA of the hip reported no change in pain, stiffness or physical function while waiting for joint replacement surgery, whereas patients with OA of the knee deteriorated on the stiffness and total scales of the WOMAC. This suggests a difference in patient selection, referral pattern or disease development between the patient categories.