Anaesthesia
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An obstetric patient had a subarachnoid block during attempted extradural analgesia for labour. The sensory block extended to T1 and was accompanied by hypotension. The analgesia lasted 3 hr. after which sensory and motor function recovered quickly. The local anaesthetic agent used was 2% 2-chloroprocaine.
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Randomized Controlled Trial Comparative Study Clinical Trial
Extradural analgesia in labour. A comparison of 2-chloroprocaine hydrochloride and bupivacaine hydrochloride.
Chloroprocaine hydrochloride 2% and bupivacaine hydrochloride 0.375% in 10-ml doses of plain solutions were studied in a randomised blind manner as the agents for continuous lumbar extradural analgesia in labour. Twenty-four patients were assessed for the speed of onset, duration of action, degree of motor blockade, dermatomal spread, arterial hypotension, and the incidence of unblocked segments. ⋯ Chloroprocaine exhibited more marked motor blockade and a lower incidence of unblocked segments. The dermatomal spread and effect on arterial pressure were similar in both groups.
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Biography Historical Article
Arthur Edward James Barker 1850-1916. British pioneer of regional analgesia.