Anaesthesia
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Randomized Controlled Trial Clinical Trial
Premedication for day case surgery. A study of oral midazolam.
A double-blind, between-patient trial was used to assess midazolam 7.5 and 15 mg as oral premedication for day case surgery. Midazolam 7.5 mg did not produce significant anxiolysis or sedation in comparison to placebo as measured by patient self-assessment linear analogue scales and observer scores. ⋯ Psychomotor performance assessed by digital-symbol substitution tests was significantly impaired by midazolam, in both doses, throughout the period of investigation. Midazolam 15 mg orally provides good premedication but the prolonged effects make it unsuitable for short-stay patients.
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Randomized Controlled Trial Clinical Trial
Nausea and vomiting after prostaglandins in day case termination of pregnancy. The efficacy of low dose droperidol.
The antiemetic effects of low dose droperidol (0.25 and 0.5 mg) and a placebo were compared in patients who had received prostaglandin for day case termination of pregnancy. The incidence of nausea and vomiting was high. Low dose droperidol significantly reduced postoperative nausea and vomiting without any delay in immediate recovery or discharge home (p less than 0.05). Droperidol 0.25 mg was equally effective as an antiemetic, as 0.5 mg.
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Case Reports
Cardiovascular collapse following epidural anaesthesia for Caesarean section in a patient with aortic incompetence.
A death following epidural anaesthesia for Caesarean section in a patient with aortic incompetence and pre-eclampsia is described. Possible hazards of epidural anaesthesia in aortic incompetence are described and it is suggested that reduction of total peripheral resistance is contraindicated in such patients.