Anaesthesia
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A case of atypical headache presenting following otherwise unremarkable epidural analgesia in labour is presented. Although there was no suggestion of accidental dural puncture during insertion of the epidural catheter, and despite the unusual features of the headache and complicated case history, an epidural blood patch was performed 13 weeks post-partum, with improvement of the patient's symptoms. A repeat epidural blood patch 2 weeks later completely resolved her headache.
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Randomized Controlled Trial Clinical Trial
The minimum effective doses of pethidine and doxapram in the treatment of post-anaesthetic shivering.
This study was designed to find the minimum effective doses of doxapram and pethidine to stop post-anaesthetic shivering. Two hundred and twenty healthy patients who shivered following routine surgery were allocated randomly to receive one of 10 doses of doxapram (0.18, 0.23, 0.29, 0.35, 0.41, 0.47, 0.7, 0.93, 1.17 and 1.4 mg.kg-1), one of five doses of pethidine (0.12, 0.18, 0.23, 0.29 and 0.35 mg.kg-1) or saline. Probit analysis demonstrated that the number of patients who stopped shivering with doxapram was independent of the amount of drug given in this dose range. ⋯ We conclude that 0.35 mg.kg-1 of pethidine is the minimum dose required to treat post-anaesthetic shivering effectively. We also conclude that 0.18 mg.kg-1 of doxapram is as effective as 1.4 mg.kg-1 in the treatment of post-anaesthetic shivering. Further study is required to find the minimum effective dose of doxapram.
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We have sought to define a way in which nitrous oxide can be safely and universally used at minimal to low flows by utilising a circle system with a controlled leak provided by a standard gas analyser sampling line and a fresh gas supply of 50% nitrous oxide in oxygen, entering from a trunk interposed between the ventilator and the circle system. Although preliminary calculations suggested that this arrangement was likely to work, it was found that 13 of 23 patients studied prospectively developed an inspired oxygen fraction below 0.3. We conclude that, although this arrangement provides a new means of introducing nitrous oxide into the circle breathing system, it does not appear inherently safer or more convenient than the conventional route.
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Twenty-four patients were given a loading dose of rocuronium 1.0 mg.kg-1 intravenously followed by boluses of 20 mg (n = 19) and 10 mg (n = 24) after return of T1 of the train-of-four to 5% of control. Neuromuscular function was assessed using a Relaxograph. The time was recorded for the return of T1 to 5% after the administration of the boluses and subsequently an infusion of rocuronium was started. ⋯ The predictive accuracy of the 10 mg bolus was assessed in a further 10 patients. At the termination of the infusion three patients had a T1% that was outside the desired range of 3-7%. A 10 mg bolus that lasts 6 min indicates a need for an infusion of at least 60 mg.h-1, 8 min (50 mg.h-1), 10 min (40 mg.h-1), 15 min (30 mg.h-1), 24 min (20 mg.h-1) and 34 min (15 mg.h-1).