Anaesthesia
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Randomized Controlled Trial Comparative Study Clinical Trial
Anaesthesia and the QT interval. Effects of isoflurane and halothane in unpremedicated children.
The effects of isoflurane and halothane on the QT interval were investigated during induction of anaesthesia. Fifty-one unpremedicated, ASA grade 1 children were studied. Anaesthesia was induced with either isoflurane (n = 25) or halothane (n = 26) and was maintained to the end of the study with end-tidal concentrations of between 2.5% and 3%. ⋯ In the halothane group, one child developed repolarisation changes while arrhythmias were observed in 10 children. There were no adverse sequelae. It is concluded that halothane may be a better anaesthetic agent than isoflurane for use in children with a prolonged QT interval.
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Review Multicenter Study
Consensus use of desmopressin and antifibrinolytics in three university clinics.
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Comparative Study Clinical Trial Controlled Clinical Trial
Anaesthetic induction time for tracheal intubation using sevoflurane or halothane in children.
The current study was designed to determine the anaesthetic induction time required for tracheal intubation (TimeEI) with equipotent inspired concentrations of 5% sevoflurane and 2.5% halothane in oxygen. TimeEI that prevents 50% and 95% of patients from coughing and gross purposeful muscular movements after intubation was defined as TimeEI50 and TimeEI95, respectively. Thirty-six patients aged 1-7 years were enrolled in the study. ⋯ Determination with this method revealed that TimeEI50 and TimeEI95 for the sevoflurane/halothane groups were 147/214 s and 194/255 s, respectively. In conclusion, it is possible to determine TimeEI using an inspired sevoflurane concentration of 5% and halothane 2.5% in oxygen. The technique with 5% sevoflurane seems more practical for paediatric anaesthesia induction in busy clinical situations.
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Randomized Controlled Trial Clinical Trial
Interactions between epidural analgesia and antifibrinolytics.