Der Anaesthesist
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Comparative Study Clinical Trial
[Airway leak pressure of the ProSeal laryngeal mask airway. Comparison with and without a gastric tube placed through the drain-tube].
The ProSeal laryngeal mask airway (PLMA) has been studied in numerous investigations and the airway leak pressure (P(leak)) is often used as a primary end-point, particularly in comparative studies with other supraglottic airway devices. The PLMA offers the opportunity to place a gastric tube through the drain-tube and P(leak) measurement can take place both with and without a gastric tube. With this study we tested the hypothesis that the use of a gastric tube influences the P(leak). ⋯ Placement of a gastric tube through the drain-tube of the PLMA does not influence the P(leak). Providing the same method of measurement has been used, P(leak) values from different studies obtained with or without a gastric tube in place are comparable.
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The propofol infusion syndrome is a rare but potentially lethal complication resulting from a prolonged continuous administration of propofol. It was first described in the beginning of the 1990's and in recent years there have been frequent reports of problems in association with the use of propofol sedation. ⋯ The pathophysiology of this syndrome appears to involve a disturbance of mitochondrial metabolism induced by propofol. Our report involves a case of propofol infusion syndrome in a patient having undergone cardiac surgery.
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Review Meta Analysis
[Perioperative administration of beta-blockers. Critical appraisal of recent meta-analyses].
The perioperative administration of beta blockers is a controversial issue. Numerous trials failed to show any significant benefit or disadvantage because of low event rates and insufficient statistical power. ⋯ There is still no clear evidence to prove a significant benefit for the unselected perioperative use of beta blockers in patients undergoing non-cardiac surgery. While high-risk patients and those undergoing major surgical procedures seem to profit, low-risk patients may be more harmed than helped by this intervention. The fact that 3 meta-analyses raising the same question produced substantially different results, underlines the importance of critically appraising each meta-analysis.
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The expected cost explosion in transfusion medicine (increasing imbalance between donors and potential recipients, treatment of transfusion-associated complications) increases the socio-economic significance of specific institutional transfusion programs. In this context the estimated use of the patient's physiologic tolerance to anemia enables 1) the tolerance of larger blood losses (loss of "diluted blood"), 2) the onset of transfusion to the time after surgical control of bleeding to be delayed and 3) the perioperative collection of autologous red blood cells. The present review article summarizes the mechanisms, influencing factors and limits of this natural tolerance to anemia and deduces the indication for perioperative red blood cell transfusion. ⋯ The current recommendations coincide to the effect that perioperative red blood cell transfusion 1) is unnecessary up to a Hb concentration of 10 g/dl (6.21 mmol/l) even in older patients with cardiopulmonary comorbidity and 2) is only recommended in cases of Hb <6 g/dl (<3.72 mmol/l) in otherwise healthy subjects including pregnant women and children. Critically ill patients with multiple trauma and sepsis do not seem to benefit from transfusions up to Hb concentrations >9 g/dl (>5.59 mmol/l). In cases of massive hemorrhaging and diffuse bleeding disorders the maintenance of a Hb concentration of 10 g/dl (6.21 mmol/l) seems to contribute to stabilization of coagulation.