Der Anaesthesist
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Review Retracted Publication
[Volume replacement in critically ill intensive-care patients. No classic review].
Effective fluid therapy is a mainstay of managing the critically ill. The ideal kind of volume replacement in this situation still remains a challenge. In spite of an immense number of contributions to this problem there is still no solution yet. ⋯ However, there seems to be no convincing clinical advantage on patients' outcome for either solution. The lack of acceptance of synthetic colloids such as hydroxyethyl starch (HES) solution for volume replacement is most likely due to reports on abnormal coagulation function. This cannot be used as an argument when new modern HES preparations with low molecular weight (70,000 or 200,000 dalton) and low degree of substitution (0.5) are used.
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Randomized Controlled Trial Multicenter Study Clinical Trial
[Ondansetron. Prophylaxis and therapy of nausea and vomiting following major gynecologic procedures. Results of a national multicenter study].
This investigation was conducted as a national multicenter study to evaluate effectiveness and safety of prophylactic and therapeutic ondansetron for postoperative nausea and vomiting (PONV) in major gynaecological surgery. ⋯ Our investigation proves the efficiency of ondansetron 8 mg prior to induction of anaesthesia in preventing PONV. Furthermore, our results demonstrate the safety of the drug for prophylaxis and therapy.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
[Predictability and precision of "target-controlled infusion" (TCI) of propofol with the "Disoprifusor TCI" system].
In Germany a TCI-system for propofol (Disoprifusor-TCI) has been commercially available since spring 1997. We investigated the prediction error and precision of this TCI system as part of a multicentre study. Bias, precision, blood concentrations and dosage of propofol were compared with patients receiving propofol via a manually controlled infusion device. ⋯ With a precision of 27.5% the investigated TCI system (Diprifusor-TCI) showed an acceptable inaccuracy, as for TCI-systems a median prediction error of +/- 30% has to be expected due to the inherent variability of pharmacokinetic parameters. Further studies will be necessary to find out whether the investigated TCI system for propofol may offer substantial advantages.