Der Anaesthesist
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Randomized Controlled Trial Clinical Trial
Clinical neuromuscular pharmacology of AH 8165 D, an azobis-arylimidazo-pyridinium-compound.
The neuromuscular blocking properties of AH 8165 D (1,1'azobis-(3-methyl-2-phenyl-1H-imidazo-1,2a-pyridinium)dibromide) were quantitatively studied in 50 patients, undergoing extra-abdominal surgery and anaesthetized with barbiturates, nitrous oxide, fentanyl and droperidol, by means of mechanograms of the hand muscles obtained by ulnar nerve stimulation. AH 8165 D is a rapid-acting nondepolarizing agent (full effect within 1--2 min) providing good intubation conditions similar to those obtained with suxamethonium. AH 8165 D may be considered to be indicated for emergency intubation in patients with full stomach when the risk of regurgitation is high. ⋯ Repeated doses show a cumulative effect. The neuromuscular blockade can easily be reversed by an anticholinesterase drug. AH 8165 D-induced muscle relaxation is always accompanied by a dose-dependent tachycardia limiting the clinical usefulness of this new drug.
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We have studied the high nursing requirements of an intensive-care unit. We report concerning the size of the staff required and the consequences for the hospital.
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Biography Historical Article
[In memoriam Professor Dr. Ludwig Zukschwerdt].
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Comparative Study
[The influence of inhalation anaesthetics on catecholamine secretion from the adrenal medulla in vivo].
The influence of chloroform and ether on the catecholamine (CA) secretion from the adrenal medulla was investigated in cats in order to compare these effects to those of halothane and methoxyflurane studied previously. The CA concentrations in the blood of the adrenolumbar vein were measured spectrofluorometrically. During inhalation of chloroform (1.0-1.5%) no significant changes of spontaneous CA secretion were observed; contrary to that, the secretion evoked by splanchnic nerve stimulation was decreased. ⋯ The results differ qualitatively from those obtained with methoxyflurane and halothane; these anesthetics caused a pronounced inhibition of spontaneous CA output. The inhibition by ether of CA secretion evoked by splanchnic nerve stimulation was less pronounced than that caused by the other anaesthetics. By comparison of the effects of four inhalation anaesthetics we evaluated, which circulatory side effects depend on changes of CA output.