Current opinion in neurology
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This review discusses the ways that rodent models of autism spectrum disorders (ASDs) have been used to gain critical information about convergent molecular pathways, the mechanisms underlying altered microcircuit structure and function, and as a screen for potential cutting edge-treatments for ASDs. ⋯ Rodent models of ASDs coupled to new emerging technologies for genome editing, cell-specific functional and structural imaging, and neuronal activity manipulation will yield critical insights into ASD pathogenesis and fuel the emergence of new treatments.
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Endovascular therapy is a promising aspect of acute ischemic stroke treatment. The ideal population of patients who benefit from treatment remains undefined, and the status of collateral circulation at presentation may be a key feature in their identification. ⋯ In this review, we define the collateral circulation, review methods of its measurement, and present recent clinical data on its impact in endovascular therapy for acute ischemic stroke. We outline our current understandings and discuss their relevance in future directions with clinical stroke management.
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Curr. Opin. Neurol. · Feb 2015
ReviewMobile computed tomography: prehospital diagnosis and treatment of stroke.
Mobile computed tomography (CT) scanning in specialized ambulances has recently become feasible. Two randomized trials have used mobile CTs for prehospital thrombolysis. This short review summarizes the available literature on this topic and provides an outlook on potential future developments. ⋯ Mobile CTs can speed up stroke treatment, especially thrombolysis; they allow for selecting the most adequate hospital destinations; and they offer new means of stroke research.
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Herein we discuss the recent literature concerning cervicogenic vertigo including vertigo associated with rotational vertebral artery syndrome, as well as whiplash and degenerative disturbances of the cervical spine. We conclude with a summary of progress regarding diagnostic methods for cervicogenic vertigo. ⋯ Little progress has been made over the last year concerning cervicogenic vertigo. As neck disturbances combined with dizziness are commonly encountered in the clinic, the lack of a diagnostic test that establishes that a neck disturbance causes vertigo remains the critical problem that must be solved.
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The purpose of this review is to examine recent advances in the diagnosis and treatment of mild traumatic brain injury with attention to the neurosensory sequelae. ⋯ It is clear from this review that mild traumatic brain injury is a rapidly growing public health issue and it vital for those who see these patients to be well versed in the neurosensory manifestations so that appropriate diagnosis and treatment are provided and accurate prognostic implications can be provided for patients and their families.