Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
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Comparative Study
Standard and higher doses of atropine in a canine model of pulseless electrical activity.
To determine whether standard or increased doses of atropine improve the return of spontaneous circulation (ROSC) rate in a canine model of pulseless electrical activity (PEA). ⋯ In this canine model of asphyxial PEA cardiac arrest, standard-dose atropine did not improve ROSC rates, compared with placebo. Increasing doses of atropine tended to decrease ROSC rates, compared with placebo and standard-dose atropine.
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Comparative Study
Mock drug delivery to the proximal aorta during cardiopulmonary resuscitation: central vs peripheral intravenous infusion with varying flush volumes.
To compare mock drug deliveries to the proximal aorta during CPR after peripheral vs central i.v. administration when the mock drug is followed by different postinfusion flush volumes. ⋯ An adequately sized postinfusion crystalloid flush (0.5 mL/kg) permits peripherally administered model drug to reach the central circulation as quickly and in equivalent concentration as centrally administered drug during CPR in a canine cardiac arrest model.