Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
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Rapid intravenous (IV) rehydration in the emergency department (ED) is required for certain children with acute gastroenteritis (AGE). ⋯ Administration of larger amounts of IV dextrose is associated with reduced return visits requiring admission in children with gastroenteritis and dehydration.
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Multicenter studies are becoming more common, and variability in local institutional review board (IRB) assessments can be problematic. ⋯ There was substantial variation in IRB assessment of a standard protocol in this study. The burden of the application process contributed to some investigators not participating, but the majority of investigators remain enthusiastic about multicenter research. A national IRB may streamline the review process and facilitate multicenter clinical research.